Thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis.

Molecular Characterization of Hypothalamo– Pituitary-Thyroid Genes in Pig (Sus Scrofa)

Hypothalamus, extensively connected with other brain regions, is the vital bridge between nervous system and endocrine system. It exerts its regulating function on endocrine system mainly via the pituitary, which is the central endocrine organ in vertebrate animals. Except the growth hormone, most of the hormones secreted by pituitary have their specific target organs. For example, thyrotropin ...

ACTH Adrenocorticotropic hormone CRF/CRH Corticotrophin releasing factor/hormone DALY Disability-adjusted life years DHEA Dehydroepiandrosterone DHEAS Dehydroepiandrosterone sulfate DNA Deoxyribose nucleic acid FSH Follicle stimulating hormone GH Growth hormone GHRH Growth hormone releasing hormone GnRH Gonadotropin releasing hormone HPA Hypothalamo–pituitary–adrenal axis

The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine.

BACKGROUND Thyroidectomized patients need variable doses of levothyroxine (LT4) to obtain target thyroid-stimulating hormone (TSH) levels. Individual feedback set-points have been hypothesized and the influence of several genes in the regulation of the pituitary-thyroid axis has been demonstrated. OBJECTIVES We hypothesized that genetic variants of the TRHR gene could be associated with a dif...

Spinal and supraspinal analgesic effects of Nimodipine : The role of Hypothalamo-Pituitary-Adrenal(HPA) axis .

Nimodipine, an L-type calcium channel blocker, can induce analgesia. However, it is not clear that this analgesic effect is at the level of spinal or supraspinal pain pathway. In addition, it has been reported that the analgesic effect of nifedipine, another L-type calcium channel blocker is related to the HPA axis, but there is no report indicating the role of this axis in the analgesic eff...

Regulation of TRH neurons and energy homeostasis-related signals under stress.

Energy homeostasis relies on a concerted response of the nervous and endocrine systems to signals evoked by intake, storage, and expenditure of fuels. Glucocorticoids (GCs) and thyroid hormones are involved in meeting immediate energy demands, thus placing the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-adrenal axes at a central interface. This review describes the mode of reg...